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This PEGI content descriptor lets us know that the video game may contain Drugs or references to illegal substances. These may be available in real life or a fictional substance that has distinct parallels to real life.
The depiction of drugs within video games will always only be seen within PEGI 16 and PEGI 18 video games.
Some Examples of games with a depiction of drugs are Thief by Square Enix and Hitmans Blood Money by Eidos Interactive.
http://hitman.com/
http://thief-four.com/